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  What is Jaundice? Symptoms, Causes, and Treatment Visit Overview Jaundice is a condition in which the skin, sclera (the whites of the eyes), and mucous membranes turn yellow as a result of high bilirubin levels in the blood.   Jaundice can affect people of all ages and can signal a serious problem with the function of red blood cells, the liver, the gallbladder, or the pancreas. Visit What factors contribute to jaundice? Bilirubin is a yellow substance produced naturally by the breakdown of red blood cells. The liver removes bilirubin from the blood and transports it to the bowels for elimination. Jaundice occurs when bilirubin accumulates faster than the liver can break it down.   Jaundice can be caused by a variety of factors.   Hepatitis A, B, C, D, and E are all viruses that can cause temporary liver inflammation. Chronic inflammation can also be caused by types B and C. Alcoholic Liver Disease refers to liver damage caused by excessive, long-term alc...